Currently there’s 2 Alzheimer’s Stem Cell Therapy Trials that are recruiting now in the US.
We have collated a complete list of every Stem Cell Therapy trial for Alzheimer’’s currently recruiting in the US as of December 2025. So you find the trial that fits your specific condition.
Alt Treatment does not recruit for or promote any specific clinical trials. If you’re thinking about participating, final decisions regarding participation should be made in consultation with qualified medical professionals.
If you need guidance on how to apply or check your eligibility, reach out to our team, we’re more than happy to assist.
Phase II Alzheimer’s Stem Cell Trial Trial Currently Recruiting : University of Miami: USA
You can read more about the study on their clinical trials page.
Who’s Running this Trial?
- This trial is sponsored and led by Dr. Bernard (Barry) Baumel at the University of Miami in Florida.
Dates & Participants
- Start Date: 2025-04-29
- Estimated Study Completion Date: 2026-06-15
Participants
- Sample Size: The study plans to enroll a small group of 8 participants.
- Ages: 55 to 90 years old.
- Eligibility Focus:
- Participants must have a diagnosis of probable Alzheimer’s disease (moderate to severe stage) and have been experiencing behavioral symptoms for at least four weeks.
- They must already be on a stable dose of antipsychotic medication for at least four weeks before the stem cell infusion.
- Participants also need a reliable family member or friend who can answer questions about their behavior.
- People with dementia other than Alzheimer’s, severe depression, recent cancer, or certain uncontrolled medical conditions are not eligible.
Study Details
What are They Looking At?
- The main goal is to see if the stem cell infusion can reduce behavioral problems associated with Alzheimer’s disease.
- Researchers also want to find out if the treatment might allow patients to lower the dose or reduce the number of antipsychotic medications they need to take.
- Although it’s not the primary focus, they will also be monitoring the safety of the infusion.
Type of Cells Used: Human Mesenchymal Stem Cells (hMSCs)
- What they are: The study is using a general category of cells called human Mesenchymal Stem Cells. These are known for their potential healing and anti-inflammatory properties.
- The Goal: The idea is that these cells might help calm the inflammation or other processes in the brain that contribute to the behavioral issues seen in Alzheimer’s disease.
- Cell Source: We don’t know where these hMSCs come from or if they are from the patient or a donor.
Dosage
- Each participant receives a single infusion containing approximately 25 million Mesenchymal Cells.
Delivery Method
- The treatment is delivered as a one-time IV infusion.
- This is an open-label, single-group study.
- All 8 participants will receive the stem cell treatment.
- There is no placebo group for comparison in this pilot study.
What They’re Measuring
- The researchers will track changes over a 12-week period after the infusion.
Primary Goal
- Behavioral Symptoms: The main measurement is the change in the score on the Neuropsychiatric Inventory.
- This questionnaire assesses behavioral problems like agitation, delusions, and apathy in dementia patients.
- A lower score indicates improvement.
Other Outcomes
- Medication Use: Tracking whether the dose or total number of antipsychotic medications changes between the start and end of the 12-week study period.
Next Steps
Follow-up Schedule
- This is a short pilot study.
- Participants will be involved for a total of up to 12 weeks.
- The main effects of the single infusion will be measured during this period.
- The study record doesn’t mention longer-term follow-up beyond this period.
Study Requirements
Please review the criteria below to see if you qualify.
Who Can Join
You Cannot Join If
We know it’s confusing & difficult to understand if your eligible for different trials. Talk to our team who can help you understand if you’re a fit.
Phase I Alzheimer’s Stem Cell Trial Currently Recruiting: University of Texas, United States
You can read more about the study on their clinical trials page.
Who’s Running It:
- The trial is being conducted at The University of Texas Health Science Center at Houston.
Dates
- Start Date: February 2025
- Primary Completion: December 2026
- Full Study Completion: January 2027
Participants:
- 12 adults between 60 and 80 years old who are in the early stages of Alzheimer’s or at high risk of developing it.
Study Details
What They’re Testing:
- This study is testing whether stem cells taken from a person’s own fat tissue can help reduce brain inflammation and slow down memory loss.
- Participants will undergo a fat biopsy to collect stem cells.
- They’ll receive 4 IV infusions of their own stem cells over a 13-week period.
- Each infusion contains about 200 million cells in a saline solution.
What They’re Measuring
Primary Outcomes:
- Changes in brain inflammation, tracked using PET scans and biomarkers like TSPO (a signal of activated brain immune cells).
- Inflammatory markers in spinal fluid (CSF).
Secondary Outcomes:
- Safety: number of side effects.
- Changes in memory and thinking using tests like MMSE and RBANS.
- Changes in Alzheimer’s-related proteins in spinal fluid (like Tau, Amyloid-β, and Nf-L).
- Brain metabolism changes via FDG-PET scans.
- Daily functioning, measured using the Lawton IADL scale.
- Immune markers in blood and spinal fluid.
Study Requirements
Please review the criteria below to see if you qualify.
Who Can Join
You Cannot Join If
We know it’s confusing & difficult to understand how to apply for trial like these. Talk to our team who can help walk you through what you need to do
Risks of joining a Alzheimer’s Stem Cell Trial
Stem cell therapy is still experimental, especially in Alzheimer’s. There are important risks to understand before joining a trial:
- We don’t fully know the long-term effects
- Scientists are still learning how stem cells behave in the brain over time. There may be risks that don’t appear right away.
- Possible immune reactions
- Even if the cells come from your own body, there’s still a chance your immune system may react in unexpected ways.
- Infection or bleeding from the procedure
- Some studies involve surgery or infusions that carry risks like infection, bleeding, or damage to nearby tissue.
- Side effects from anesthesia or sedation
- If surgery is involved, there may be side effects related to the medicines used to help you sleep during the procedure.
- Uncertain benefit
- These treatments are experimental. There is no guarantee they will improve memory or slow the disease.
- Frequent tests and check-ups
- Trials often require regular visits, blood tests, brain scans, and spinal taps, which can be uncomfortable or tiring.
- Time commitment
- Some studies last a year or more and may require frequent follow-up appointments and travel.
No, for most Trials it won’t cost you.
There are certain “self-funded” trials, which are mainly treatments being offered by Stem Cell Therapy clinics.
Stem cell therapy for Alzheimer’s is still experimental, but yes, some clinics are already offering it. Early studies show it may reduce inflammation and slow memory loss but it’s not a proven or approved treatment yet.
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