On this article, we’re purely breaking down what the research is saying for Stem Cells treating hair loss.

If you want to know more about treatment process and how Stem Cell Therapy works for hair loss, check out our article on the full process here.

Best Stem Cell Therapy clinics for Hair Loss

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Top Stem Cell Therapy Clinics in Colombia for Hair Loss

Umbilical Cord Derived Stem Cells Higher Dosage Treatments Certified Lab

Alevy specializes in stem cell and exosome therapy, using umbilical cord-derived MSCs to treat a wide variety of conditions, from Diabetes, Multiple Sclerosis to Osteoarthritis & Orthopaedic injuries. Their medical team brings over 15 years of experience in pain management, tissue regeneration, and immune system modulation. With three world-class clinics in Medellín, Bogotá, and Pereira, you have options on where you want treatment!

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Umbilical Cord Derived Stem Cells Higher Dosage Treatments Certified Lab

Kyron Stem Cells is a Stem Cell Therapy clinic that focuses on a variety of treatments, including joint pain, chronic fatigue, autoimmune issues, and overall wellness. The clinic is led by Dr. Carlos Rojas, who has been working with stem cells since 1991 and has over a decade of experience in functional and hormone-based medicine. He is known for creating treatment plans that are genuinely personalized, based on each patient’s biology and lab results.

View Full Profile

Clinical Studies: What the Science Says

Adipose Derived stem cell conditioned media and minoxidil for hair regrowth in in male Androgenetic Alopecia: Indonesia

You can read more about this study here & here,

Who’s Running It:
The study was conducted by doctors at Dr. Cipto Mangunkusumo Hospital and Universitas Indonesia, supported by the National Research and Innovation Agency (BRIN). It’s the first double-blind randomized trial in Indonesia testing whether a byproduct of stem cells — not the cells themselves — could help regrow hair in men with male-pattern baldness.

Participants:
37 adult men, aged 25 to 59, all diagnosed with androgenetic alopecia (common male-pattern baldness).

To qualify, they had to:

• Have stopped using minoxidil or anti-androgens for at least a month

• Have no other type of hair loss

• Not be on treatments like PRP or finasteride in the last 6 months

What They’re Testing:
The study looked at whether “stem cell conditioned media” (ADSC-CM),  a liquid full of healing proteins naturally released by stem cells could help stimulate hair growth when injected into the scalp. Especially when used alongside topical 5% minoxidil, a common hair loss medication.

What is Conditioned Media?

• This isn’t a stem cell transplant. No live stem cells were injected.

• Instead, doctors used the cell-free fluid that stem cells had been grown in  like a “stem cell smoothie” full of the growth factors stem cells naturally release.

• These ingredients (like VEGF, IGF-1, and TGF-β) are thought to help repair tissue, improve blood flow, and stimulate hair follicles.

Treatment Setup:

• Each participant’s scalp was split down the middle:

• One side got injections of the stem cell-conditioned media (ADSC-CM)

• The other side got just saline (placebo)

• Participants also applied 1 ml of 5% topical minoxidil to their whole scalp twice daily.

There were two treatment groups:

• Non-concentrated ADSC-CM

• Concentrated ADSC-CM (a stronger dose)

• Injections were given every 2 weeks for 6 weeks (3 sessions total).

How the Conditioned Media Was Made:

• Stem cells were grown from donated human fat tissue.

• The cells were cultured in a lab and then removed. Only the nutrient-rich liquid they left behind was kept.

• This fluid was filtered, frozen, and in one group, concentrated further to boost its effects.

• No live cells were injected, just the signaling molecules they produce.

What They’re Measuring:

Using video trichoscopy, researchers measured:

• Hair count

• Hair density

• Hair thickness

• Terminal vs. vellus (fine) hair ratio

• They also asked patients to rate their satisfaction with results on a 7-point scale.

Results So Far:

• Hair regrowth was seen on both sides of the scalp, even on the placebo side.
  “Hair count, density, and thickness improved significantly on both sides after 6 weeks.” – Study findings, page 6

• 81% of participants were “very satisfied” with their results (score of 7 out of 7).

• There were no serious side effects. Some had mild itching, irritation, or temporary redness.

Was There a Difference Between Groups?

No statistically significant difference was found between:

• The stem cell media and placebo sides

• The concentrated and non-concentrated groups

• This suggests the minoxidil + injection process alone may have caused most of the benefit  or that the stem cell media effect was too subtle to detect in just 6 weeks.

Possible Reasons Why Both Sides Improved:

• Minoxidil works well on its own

• Injections cause microtrauma, which can stimulate hair growth (like microneedling)

• Growth factors may have spread across the scalp from the treatment side

Final Takeaway:

• This trial shows that stem cell-conditioned media is safe, and it may help regrow hair when paired with minoxidil.

• But in this short trial, it didn’t outperform placebo by a clear margin

2. RepliCel Life Sciences RCH-01

What Is RCH-01?

RCH-01 is a treatment created by a company called RepliCel Life Sciences to help people regrow hair. It uses a person’s own cells, taken from the back of their scalp, to try to wake up thinning or dormant hair follicles and help them grow hair again. Otherwise known as Dermal Sheath Cup Cells.

You can read the full study here.

How Did the Study Work?

• Who took part?
  65 people total: 50 men and 15 women between ages 33 and 64, all with pattern hair loss (the kind that slowly thins over time).
  
• What was done?
  Doctors took cells from the back of each person’s head, grew more of those cells in a lab, and injected them back into 4 spots on their scalp.
  
• What were the injections?
  
  • Low Dose: 300,000 cells (3.0 × 10⁵)
  • A medium dose: 1.5 million cells (1.5 × 10⁶)
  • A high dose: 7.5 million cells (7.5 × 10⁶)
  • A placebo (no real cells, just a control)

• What did they measure?
  
  • How many new hairs grew (hair count)
  • How thick the hairs were
  • Measured at 3, 6, 9, and 12 months after treatment

• What Did the Study Find?
• The low dose gave the best results!
  
• After 6 and 9 months, that area had:
  
  • More hairs than the placebo area
    
  • Thicker hair strands
    
• It worked well for both men and women
  
• No serious side effects were reported
  
• The improvements started to fade by month 12

What Were the Limits?

• They didn’t test if smaller doses might still work
  
• The effects didn’t last long-term
  
• They only tested it once per person, so we don’t know if repeat treatments would work better

What Does This Mean?

• This kind of hair treatment looks safe and promising
  
• It gave moderate hair growth results in both men and women
  
• The best results were with the lowest dose, which is unusual and needs more research
  
• Because the effects wore off after about 9 months, people would likely need follow-up treatments for long-term results

Reviews: What Are They?

Studies involve experiments or trials to test something, while reviews analyze and summarize lots of different studies. Reviews give you the bigger picture but don’t bring in new experimental data. Now, let’s look at two important reviews on stem cells for hair loss.

1. 2023 Review on Androgenic Alopecia Trials

What the Review Looked At (here’s the link)

This review looked at 12 high-quality clinical trials from the past decade that tested how well stem cell treatments work for hair loss. Specifically for androgenetic alopecia, the most common type of hair thinning in both men and women. The treatments fell into two main types:

• Cellular, which use actual living stem cells

• Acellular, which use powerful substances made by stem cells like growth factors and proteins to stimulate hair growth

The goal? To find out whether these cutting-edge approaches are safe, and more importantly, if they really help people grow back their hair.

The 5 Categories of Stem Cell Treatments Reviewed

Hair Follicle–Derived Stem Cells (HF-MSCs)
These use cells taken from a person’s own hair follicles usually the back of the head. They are either injected directly or processed into a solution to stimulate nearby hair follicles. Most trials showed an increase in hair density and shaft thickness, though results tended to fade after a few months without retreatment.

Adipose (Fat) Tissue–Derived Stem Cells (ADSCs)
This group included both live fat-derived stem cells and their secretions (called conditioned media). Treatments were given through scalp injections or topical applications, sometimes paired with microneedling or minoxidil. These were among the most effective approaches, showing consistent hair regrowth and thickness improvements in multiple studies.

Bone Marrow–Derived Mononuclear Cells (BMMCs)
These involve extracting stem cells from a person’s bone marrow and injecting them into the scalp. The trial showed promising results for patients who didn’t respond to traditional treatments, but this method was more invasive and came with more side effects like pain and bruising.

Umbilical Cord–Derived Mesenchymal Stem Cells (hUCB-MSCs)
These treatments used paracrine factors,healing molecules secreted by stem cells from donated umbilical cord blood. Applied as a topical serum, they showed strong results in increasing hair thickness and growth, with no serious side effects reported.

Stem Cells from Exfoliated Deciduous (Baby) Teeth (SHED-CM)
This newer approach used cell-free solutions derived from the pulp of naturally shed baby teeth. One trial found it effective in about 75% of participants, with only mild side effects like scalp irritation or small bruises.

Overall Findings

The bottom line? The researchers found that stem cell treatments, whether using live cells or just the healing stuff they produce are generally safe and do help with hair regrowth. People saw thicker, fuller hair in many of the studies. 

The catch? The results didn’t always last forever, and some treatments worked better than others. Still, these therapies show real promise, especially when used alongside proven options like hair transplants or medicated creams. The authors also pointed out that we need more long-term studies to figure out the best way to use these treatments and make results more reliable for everyone.

2.Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss:Italy

You can check out the full review here.

The researchers looked at how stem cells and growth factors help people regrow hair, especially people with androgenic alopecia (AGA). Which is the most common type of hair loss in men and women.

They reviewed several therapies and clinical studies to see:

• Which cell types (like fat stem cells or hair follicle stem cells) are useful?
  
• What actually happens in the body when these cells are used?
  

• Which treatments work best based on science and real-world results?

What They Found

1. Hair Regrowth Is Controlled by Special Signals

• Your hair grows in cycles  and stem cells control that cycle.
  
• The Wnt signaling pathway is like a switch that turns hair growth on.
  
• Other helpful proteins (called growth factors) like VEGF, FGF, IGF-1 help create new blood vessels, boost cell survival, and wake up hair follicles.
  

2. Three Types of Treatments Seem to Work

A. Platelet Rich Plasma (PRP)

• This is where doctors take your blood, spin it, and inject the platelet-rich part into your scalp.
  
• Platelets release growth factors that tell your body: “Hey! Grow more hair here!”
  
• In clinical studies:
  
  • People grew more hair (up to 31% increase in density).
  • The hairs also became thicker and healthier.
  • Works well for early-stage hair loss.

  B. Fat-Derived Stem Cells (AD-SVFs)

• Doctors take a little fat from your body (like with liposuction), extract stem cells, and inject them into the scalp.
  
• These fat-derived stem cells release helpful signals to wake up sleeping hair follicles.
  
• In studies:
  
  • People grew more hairs (as much as 31 more hairs per square cm).
  • Hair got denser and fuller over 6+ treatments.
  • Some patients used the conditioned liquid from the stem cells (not the cells themselves) and still saw growth.

C. Hair Follicle Stem Cells (HFSCs)

• These are stem cells taken from your own scalp,  a tiny skin biopsy is spun to isolate cells.
  
• They’re not grown in labs, just cleaned and injected back in.
  
• In early studies:
  
  • People had noticeable improvements in hair growth.
  • These treatments are promising because they’re minimally manipulated and can be done in a single surgery.
  • But the study also found that in people with advanced hair loss, these follicle stem cells are still present yet the cells needed to activate growth (called progenitor cells) are missing or inactive. Which may limit how effective this treatment is in later stages.

3. The Best Therapies Are “Simple but Smart”

• Treatments that don’t manipulate the cells too much (like not growing them in a lab) are:
  
  • Safer
  • Faster
  • Easier to get approved by the FDA or European agencies
• So doctors can legally use these methods in clinics as long as they follow safe handling procedures.

4. It’s Still Early. But Looks Promising

• These therapies won’t work for everyone, more studies are needed.
  
• But the combination of fat stem cells and PRP seems the most effective right now.
  
• Hair follicle stem cell therapies are newer, but could be the future.
  
• Standardization (using the same method every time) is still a challenge in this field.

3. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss

Check out the full review here.

What They Looked At

The researchers wanted to understand how stress causes hair loss, especially a condition called alopecia areata and whether stem cell secretions, called the secretome, can help treat it.

They reviewed dozens of studies, including lab tests and animal experiments, that looked at:

• How stress affects the body and leads to hair loss.
• How stem cells, or more specifically, the natural substances they release, might help regrow hair.

What They’re Trying to Find Out

They were looking for answers to these big questions:

• Why does stress cause hair to fall out?
  
• Can stem cells, or just the helpful fluids they release, reverse that damage and help hair grow back?
  
• Is it possible to use those fluids (the secretome) as a safer, natural treatment instead of harsh medications?

What They Found

Here’s what they discovered from all the research:

• Stress can trigger the body’s immune system to attack its own hair follicles, especially in people with certain genes.
  
• This leads to hair loss, sometimes in patches (alopecia areata).
  
• Current treatments (like creams, pills, and light therapy) don’t work well and often have side effects.
  
• Stem cells naturally release healing substances, called the secretome, that can calm inflammation, protect hair cells, and restart hair growth.
  
• In both lab tests and animal studies, these secretions helped:
  
  • Make hair thicker and grow faster.
  • Heal the damage caused by stress.
  • Restart the hair growth cycle.

What They Concluded

The authors believe that:

• Stem cell secretions (the secretome) could be a natural and powerful new treatment for stress-related hair loss like alopecia areata.
  
• It’s safer and easier than using full stem cells or medications with side effects.
  
• It shows a lot of promise but needs more human trials to figure out the right dosage, frequency, and best type of stem cells to use.

In Simple Terms:

Stress can make your body attack your own hair. The natural “juice” from stem cells might stop this, calm the immune system, and help your hair grow back. It’s not yet widely used, but the science so far looks very promising and safer than many current options.

4. 2025 Recent Advances in Drug Development for Hair Loss: Asia

What They Looked At

The researchers reviewed many recent studies and clinical trials about stem cell treatments for hair loss. Instead of running experiments themselves, they collected the latest findings from clinics, biotech companies, and scientific papers around the world, especially from South Korea, Japan, and China, where these treatments are already being tested or used.

They focused on four types of stem cell-based approaches:

• Dermal Papilla Cells (DPCs)
  
• Dermal Sheath Cup Cells (DSCs)
  
• Adipose-Derived Stem Cells (ADSCs) (from fat)
  
• Stromal Vascular Fraction (SVF) (a mixture of cells from fat tissue)

What They’re Trying to Find Out

The goal was to understand:

• Can stem cells actually help regrow hair in people with common hair loss (like male pattern baldness or autoimmune-related bald spots)?
  
• Which types of stem cells work best?
  
• Are any of these treatments safe, effective, and ready for use in clinics?
  
• Can they replace or work better than existing drugs like minoxidil or finasteride?

What They Found

• Dermal Papilla Cells (DPCs) can trigger new hair growth when injected. These are already in clinical trials (e.g., by Epi Biotech).
  
• Dermal Sheath Cup Cells (DSCs) are being used in Japan by Shiseido, and the treatment is already available there. Early results show strong improvements in both men and women.
  
• Adipose-Derived Stem Cells (ADSCs) also help regrow hair, either by injecting the cells or just using the nourishing fluid they release. These have shown very promising results in small trials.
  
• Stromal Vascular Fraction (SVF) is a mix of helpful cells from fat tissue. It improves the scalp environment, reduces inflammation, and leads to thicker, healthier hair after just a few injections.
  
• These treatments are especially popular in Asia, where regulations make it easier to offer them in clinics. In the U.S. and Europe, they’re mostly still being tested in trials.

5. Human Stem Cell Use in Androgenetic Alopecia: Poland

You can read the full review here

• The authors conducted a systematic review of 15 clinical studies involving 653 patients with Androgenetic Alopecia (AGA) to assess the effectiveness and safety of human stem cell therapies.

• Outcomes assessed: Hair density, hair count, thickness, and safety.

• Sources included: MEDLINE (PubMed), Web of Science, and Scopus.
  

Types of stem cells studied:

• Hair Follicle-Derived Stem Cells (HFSCs)

• Adipose-Derived Stem Cells (ADSCs)

• Bone Marrow Stem Cells (BMSCs) (in one study)
  

• Study types: RCTs, non-randomized controlled trials, single-arm studies, and retrospective case series
  

What They Were Trying to Find Out

The review aimed to determine:

1. Whether stem cell-based therapies improve hair growth in men and women with AGA.
   
2. How different stem cell types (HFSCs, ADSCs, BMSCs) compare in efficacy.
   
3. Whether stem cell treatments are safe and free from serious side effects.
   
4. If stem cell therapy could be a viable alternative or complement to conventional AGA treatments like minoxidil or finasteride.

What They Found

Efficacy:

• All included studies reported improvement in hair density after stem cell treatment.
  
• Most studies showed no major adverse events, only mild or transient side effects.
  
• Stem cells from hair follicles and adipose tissue were the most commonly used and effective.
  
• Results from placebo-controlled RCTs consistently favored stem cell therapy.
  
• Only one study (Tsuboi et al.) reported specific cell counts.
  
• No study compared all stem cell types head-to-head, and reporting practices were inconsistent.

Safety:

• No major side effects were reported in most studies.
  
• Minor issues included mild pain, redness, or small hematomas, especially from injections.
  
• One study (with BMSCs) reported bone pain and fatigue following G-CSF use. The most intensive protocol.

What They Concluded

Stem cell therapy for androgenetic alopecia is a promising, safe, and effective option to improve hair density in both men and women.

However, the authors emphasized:

• A need for standardized protocols (dosing, stem cell type, number of sessions).
  
• More high-quality randomized controlled trials with larger sample sizes.
  
• Comparative studies between different stem cell sources (e.g., HFSCs vs ADSCs vs BMSCs).
  
• Exploration of Wharton’s Jelly stem cells, which have potential but are under-studied

Limitations: What’s the Catch?

Here’s the reality. While stem cell therapy for hair loss shows promise, there are a few things to keep in mind:

• Lack of extensive research. While some smaller studies and trials have shown promising results, the field is still in its early stages, and there is a need for more long-term, large-scale clinical trials to confirm the effectiveness and safety of these treatments.

• Small Groups. Many trials, like the one with 37 participants, are relatively small. Bigger studies are needed to make sure the results apply to more people.

• Short Follow-Up. Most studies only follow people for a few months (like six weeks in the ADSC-CM trial). We don’t know if the benefits last for years or if repeated treatments are needed.

• Lack of Standardization: Studies use different methods, doses, and delivery types, making it hard to compare results or know what actually works best.

• Geographic Differences. The studies were done in specific regions, like Indonesia. People in different parts of the world might respond differently due to genetics and lifestyle.

What They Concluded

The authors believe stem cell therapy is one of the most exciting and effective new options for treating hair loss, especially for people who don’t respond well to existing drugs.

Key takeaways:

• Stem cell treatments can repair and reactivate hair follicles, not just slow hair loss.
  
• They may offer long-lasting results with fewer side effects.
  
• As more trials are completed, we’re likely to see stem cell therapy become a standard option in the future.
  
• However, the treatments are still expensive, and more research is needed to make them affordable and widely available.

Conclusion

The research consistently shows that stem cells help hair growth not by turning into new hair, but by releasing healing signals. Like proteins and growth factors like VEGF, IGF-1, FGF, and Wnt. Confirming that the signals matter more than the cells themselves.

Overall:

• Stem cell therapies are safe, with very few serious side effects reported.
  

• Many studies show moderate improvements in hair density, thickness, and patient satisfaction  especially when stem cells are used alongside proven treatments like minoxidil or PRP.
  

• Fat-derived stem cells (ADSCs) and hair follicle stem cells (HFSCs) are the most studied, and have shown the most consistent results in clinical trials.
  

• Benefits can appear after just a few sessions, and short-term regrowth is real. But in many cases, effects begin to fade after several months.

What the Data Doesn’t Tell Us Yet

Despite encouraging results, several key questions remain unanswered:

• Cell Dosage: We don’t yet know how much is enough. Some studies showed better results with lower doses, but dose-response relationships are still unclear.
  
• Best Stem Cell Type: No studies directly compare ADSCs, HFSCs, BMSCs, or umbilical cord stem cells. Most research has focused on what’s easiest to collect, not necessarily what works best.
  
• Number of Sessions Needed: Most trials used 1–6 treatments, but we don’t yet know how many are needed for long-term success  or how often results fade without retreatment.
  
• Standard Protocols: Methods vary widely, from injections to topical serums, with or without microneedling or medications. Making it hard to know what the “best practice” actually is.