Back pain is one of the most common and debilitating conditions, affecting millions of people worldwide. While traditional treatments like physiotherapy, painkillers, and surgery can offer some relief, they often don’t address the root cause. Enter Stem Cell Therapy, a treatment with the potential to repair damaged tissues and provide lasting relief for chronic back pain. But how does it work, and is it worth considering? 

How Do Stem Cell Treatments Help with Back Pain? The Science Explained

Stem cell therapy for back pain works by calming inflammation, repairing damaged discs and joints, and encouraging the body to heal itself naturally. In theory, these cells can turn into new disc or cartilage tissue but so far, most MRI scans haven’t shown that happening. But it could also be not many studies have looked for it closely, so we just don’t know yet.

To break it down further:

How Stem Cells Can Help Reduce Inflammation in Back Pain

Inflamed Spinal Disc

Stem Cells Releasing
Anti-Inflammatory Signals

Reduced Inflammation

To learn more about the full process, check out this article explaining how Stem Cell Therapy works in detail.

What Types of Back Pain Can Stem Cell Therapy Treat?

Stem cell therapy may help treat chronic lower back pain, herniated discs, degenerative disc disease, spinal arthritis, sciatica, and even some spinal cord injuries by reducing inflammation and repairing damaged tissues.

Back pain comes in many shapes and sizes, and not all treatments work for every type. The good news? Stem cell therapy targets several common conditions by promoting healing and reducing inflammation. Here’s a quick look at the types of back pain it may help:

1. Degenerative Disc Disease Stem Cell Treatments

Think of your spinal discs like shock absorbers. Over time, they can wear out, causing pain and stiffness. Stem cells step in to regenerate these damaged discs, potentially improving both comfort and mobility.

2. Herniated Discs Stem Cell Treatments

A herniated disc can press on your nerves, leading to sharp pain and even numbness. Stem cell therapy aims to reduce inflammation and repair the damaged disc tissue, offering relief without the need for invasive surgery.

3. Spinal Arthritis (Facet Joint Pain) Stem Cell Treatments

If arthritis in your spine makes every movement feel stiff and painful, stem cells can help calm the inflammation and improve joint health, giving you more freedom to move.

4. Sciatica Stem Cell Treatments

That shooting pain down your leg? Stem cells could help. By targeting the inflamed or compressed sciatic nerve, they may ease discomfort and encourage natural healing.

5. Can Stem Cells treat Chronic Lower Back Pain?

Yes, stem cell therapy may help with chronic lower back pain by targeting damaged spinal discs, inflammation, and slow-healing injuries. Unlike steroid injections, which only provide temporary relief, stem cells aim to repair tissue and reduce inflammation at the source.

6. Spinal Cord Stem Cell Treatments

While still experimental, early research shows promise for using stem cells to repair nerve damage and potentially restore function in cases of spinal cord injury.

How long does it take to recover from Stem Cell Treatment for back pain?

Recovery time takes 2-6 weeks to let the stem cells work. You’ll be able to walk around pretty much straight away, but you should avoid high impact activities.

Types of Stem Cells being explored for Back Pain

Doctors and scientists are trying different types of stem cells, from bone marrow, fat, and umbilical cords to see which ones work best for healing discs, easing pain, and fixing spine damage.

1. Bone Marrow Mesenchymal Stem Cells (BM-MSCs)
These are commonly used & studied for back pain caused by degenerative disc disease (DDD). BM-MSCs can potentially help repair damaged discs by promoting tissue regeneration and reducing inflammation.

2. Umbilical Mesenchymal Stem Cells (U-MSCs)
These cells are used in therapies for back pain, particularly because of their anti-inflammatory properties and potential to repair damaged tissues.

3. Adipose-Derived Mesenchymal Stem Cells (AD-MSCs)
Since these are easily harvested from fat tissue, they are a popular choice for treating back pain caused by conditions like disc degeneration. Their abundance and ability to release anti-inflammatory factors make them a viable option.

4. Neural Stem Cells (NSCs) and Neural Progenitor Cells (NPCs)
Clinics don’t typically use for back pain but are relevant in cases involving nerve damage, such as sciatica or spinal cord injuries that contribute to chronic pain. A recent Phase 1 Trial done by UC San Diego just proved that neural stem cells are safe to use for spinal cord injuries, a huge breakthrough!

5. Induced Pluripotent Stem Cells (iPSCs)
These are more experimental and not yet commonly used in back pain treatment due to their complexity and cost. However, they offer the potential to regenerate damaged tissues in the spine.

6. Extracellular Vesicles (EVs) from Stem Cells
Researchers are exploring EVs from stem cells as a less invasive way to treat back pain, delivering regenerative and anti-inflammatory signals directly to affected areas.

How Much Does Stem Cell Therapy for Back Pain Cost in the US and UK?

Stem cell therapy for back pain costs between $5,000–$50,000 in the US and £8,000–£30,000 ($10,000–$37,000 USD) in the UK, depending on the clinic, treatment type, and number of stem cells used. Here’s a deeper breakdown:

United Kingdom: In the UK, private clinics offer stem cell therapy for back pain at rates between £8,000 and £30,000 ($10,000–$37,000 USD). While prices are still high, the UK’s ability to offer higher cell volumes may provide an edge over US clinics.(Remember, only SOME UK clinics can offer higher cell volumes). Also, remember this treatment isn’t available on the NHS, so you would have to go to a private clinic if you’re in the UK!

United States: Costs typically range from $5,000 to $50,000, depending on the clinic, the type of stem cells used, and the complexity of the treatment. Advanced procedures like intradiscal stem cell injections tend to be on the higher end of the spectrum.

To look at average costs of Stem Cell Therapy in different regions, our article on Stem Cell Therapy costs in different countries might be useful!

What other countries use Stem Cells to treat Back Pain?

Countries like Colombia, Panama, Japan, Thailand and Dubai use stem cells to treat back pain.

Each country has different regulations and treatment options. Check out our guide to the best countries for stem cell therapy to compare.

What are the risks of getting Stem Cell Treatments for Back Pain?

Stem cell therapy for back pain shows promise, but it’s still experimental. Risks include limited long-term data, possible nerve irritation from injections, and the need for additional treatments for complex injuries.

Despite some promising results, it might be too soon to say whether Stem Cell Therapy for back injuries will become a standard treatment. Here’s why:

• Limited Long-Term Data: Most trials are still in their early stages. We lack robust, long term data on the effectiveness and safety of these treatments. Researchers are unsure how well the benefits will last or if there are any long-term risks.
• Nerve damage: If the injection isn’t placed correctly, it could irritate nerves and worsen pain. Most top clinics use fluoroscopy (real-time X-ray guidance) to minimize this risk and ensure precise placement.
• Need for Combined Therapies: Stem cell therapy on its own may not be enough to treat complex injuries like SCI. Researchers increasingly believe that combined treatments using stem cells alongside other therapies, like growth factors or neuroprotective drugs may be more effective in achieving meaningful recovery.

To learn more about the side effects, check out our article on the long term side effects of Stem Cell Therapy.

Stem Cell Therapy vs. Traditional Back Pain Treatments

Treatment	Cost	Effectiveness	Longevity	Risks
Stem Cell Therapy	$5,000–$50,000	Promising for reducing inflammation and repairing tissue	Potentially 1–5 years, more research needed	Experimental. Results are varied from patient to patient
Cortisone Injections	$1,000–2,500 per shot	Effective for short-term pain relief	A few months	Can weaken cartilage if overused
Physical Therapy	$50–$200 per session	Gradual improvement in mobility and strength	Varies by condition	Minimal risk; requires consistent effort
PRP (Platelet-Rich Plasma)	$2,000–$5,000	May improve healing and reduce pain	6–12 months	Mild swelling or discomfort post-procedure

What does the research say about Stem Cell Therapy for Back Pain

The research into stem cell therapy & Stem cell products for back pain is still evolving, but here are some highlights:

BRTX-100 Stem Cell Therapy for Chronic Lower Back Pain (cLDD)

(To read more about the study yourself, here’s the press release they released on May 13th 2025!)

• Who’s Running the Study?
  BioRestorative Therapies, Inc. is conducting this Phase 2 clinical trial to test BRTX-100. A stem cell treatment aimed at people with chronic lumbar disc disease (cLDD), a common cause of long-term lower back pain.
  What makes it unique? BRTX-100 uses a patient’s own bone marrow stem cells, but they’re specially grown in low-oxygen (hypoxic) conditions, which may help them survive better and repair damaged tissue more effectively.
• Who Took Part?
  The early data includes 15 participants (but the full trial will include up to 99).
  To join, patients had to have:
  – Lower back pain due to lumbar disc degeneration.
  – Persistent symptoms despite trying other treatments like physical therapy or pain medications.
• How did it Work?
  Each Patient Received:
  – A single injection of 40 million (40×10⁶) mesenchymal stem cells from their own bone marrow.
  – The injection was given directly into the damaged disc.
  – Before the injection, the stem cells were blended with something called platelet lysate. A mix of healing proteins taken from the patient’s own blood. This gives the cells an extra boost, helping them survive longer, send better signals to reduce inflammation, and kickstart the body’s natural repair process once they’re inside the damaged disc. Together, this combo may lead to better long-term relief and help some patients avoid surgery altogether.
  
  This is a randomized, double-blind study, meaning neither patients nor doctors know who got the real treatment vs. the placebo.
• Results So Far
  Safe So Far: No serious side effects have been reported up to 2 years post-injection.
  Pain & Disability Improvements: A growing number of patients showed major improvements over time. Here’s the percentage of patients who saw over 50% pain and disability reduction at different checkpoints:
  
  – Week 2: 0%
  – Week 12: 13%
  – Week 26: 46%
  – Week 52: 70%
  – Week 104: 67%
• What This Means
  These early results are super encouraging. BRTX-100 may offer a non-surgical, long-term solution for people struggling with chronic lower back pain due to disc problems.
  
  – The fact that pain and disability improvements increased over time suggests real regenerative benefits.
  – Because the treatment uses your own cells, there’s no risk of immune rejection.
• Did Stem Cells actually rebuild the disc?
  – BioRestorative didn’t track whether the stem cells turned into new disc tissue. There were no cell labels, no biopsies, and no imaging results showing new disc formation. That means there’s no direct proof the cells differentiated (transformed) into disc cells.
  
  – But what we do have is growing evidence that the treatment helped reduce pain and improve function over time without serious side effects. Given that, and the fact the stem cells were specially prepared to survive longer and release healing proteins, it’s far more likely that they worked by sending out regenerative signals (not by becoming new tissue themselves).
  
  – In simple terms: the cells acted more like coaches giving instructions, not turning into new cells themselves.
  
• Next Steps
  The trial is still ongoing and expanding to include more participants. If future data stays positive, BRTX-100 could become a new gold standard for treating lower back disc issues, especially for people trying to avoid surgery.

CELZ-201-DDT Stem Cell Therapy for Chronic Lower Back Pain

(To read more about the study yourself, here’s the press release & here’s the study page)

• Who’s Running This Study?
  Creative Medical Technology Holdings, Inc. (CELZ) is conducting this Phase 1/2a clinical trial to evaluate the safety, tolerability, and effectiveness of CELZ-201-DDT, an allogeneic (donor-derived) stem cell therapy for patients suffering from degenerative disc disease and chronic lower back pain. The just announced results in January 2025!
  
  The trial uses umbilical cord-derived mesenchymal stem cells (UC-MSCs). But here’s the interesting part, Creative Medical has modified these cells using their own process to enhance their anti-inflammatory and regenerative properties for treating chronic lower back pain.
• Who Took Part?
  – 10 participants with chronic lower back pain caused by degenerative disc disease.
  – Patients were required to have persistent pain for at least 6 months and have tried other treatments (e.g., painkillers, physiotherapy, or injections) without success.
• How Did It Work?
  Participants were randomly divided into three dose groups plus a placebo group.
  – Low-dose group: Received 6 million (6×10⁶) stem cells.
  – Medium-dose group: Received 30 million (30×10⁶) stem cells.
  – High-dose group: Received 60 million (60×10⁶) stem cells.
  – Placebo group: Received an injection without stem cells.

Each patient received six intramuscular injections (three injections per side of the lumbar paraspinal muscles) under ultrasound guidance.

• Results So Far
  – No major safety concerns – The therapy was well tolerated, with no serious adverse effects reported in the first cohort.
  – Pain Reduction – Early data suggests that patients receiving CELZ-201-DDT experienced decreased pain levels.
  – Improved Mobility – The treatment showed potential for enhancing physical function and reducing disability scores in patients.
• What This Means
  – Early results are promising, but more data is needed to confirm long-term effectiveness.
  – CELZ-201-DDT could provide a non-surgical, regenerative alternative for chronic back pain sufferers.
  – Higher doses may be more effective, but further trials are needed to determine the optimal dosage.
  – So far, there’s no evidence that the stem cells actually turned into new tissue. Instead, it looks like they worked by sending out healing signals. Reducing inflammation, calming irritated nerves, and helping the body feel better naturally.
• Next Steps
  – The trial is ongoing and continuing enrollment toward its target of 30 participants. Each patient will be followed for 12 months to evaluate long-term safety, pain relief, and functional improvements.
  

Umbilical Cord Stem Cell Product Trial for Chronic Lower Back Pain
(To read more about the study yourself, here’s the source!)

• Who’s Running This Study?
  – A South Korean biotech company, CHABiotech CO., Ltd, is behind this research. They specialize in stem cell based treatments and are testing whether their product, CordSTEM-DD, can help with chronic lower back pain caused by degenerating spinal discs.
• Who Took Part?
  – 36 adults (ages 19–69) dealing with serious lower back pain for at least 6 months.
  – They had already tried other treatments (like painkillers, physiotherapy, or injections) without success.
• How Did It Work?
  – Patients were randomly placed into three groups:
  – Low dose group: Got 7 million umbilical cord stem cells (0.7 × 10⁷).
  – High dose group: Got 21 million umbilical cord stem cells (2.1 × 10⁷).
  – Placebo group: Got an injection with hyaluronic acid (HA) and saline, but no stem cells.
• So, is this the same as traditional stem cell therapy?
  – Nope. This is a pre-made, lab-grown stem cell product (CordSTEM-DD), not a personalized treatment using the patient’s own stem cells.
  – Think of it like an “off-the-shelf” stem cell treatment—standardized and ready to go, rather than a custom-made procedure where stem cells are taken from a patient and reinjected.
• Why Haven’t We Seen the Results Yet?
  – The study officially ended in April 2023, so why no results?
  – The company submitted them in October 2023, but ClinicalTrials.gov sent them back for revisions in April 2024 (probably to fix missing details or clarify data).
  – They resubmitted in April 2024, and the next review cycle was set for August 2024.

Delays like this aren’t unusual—clinical trial data needs to be rock-solid before it’s published. Hopefully, we’ll know soon whether this stem cell product is the real deal for back pain!

Companies are also seeing whether using Wharton’s Jelly can help with lower back pain too:

Wharton’s Jelly Study

• Who’s Running This Study?
  – R3 Stem Cell, a U.S.-based regenerative medicine company, is testing whether Wharton’s Jelly (WJ) allograft—a material from umbilical cord tissue—can help people with chronic lower back pain. (if you want to read about this yourself, here’s the source!)
• Who’s Taking Part?
  – 100 adults (ages 20+) with long-term lower back pain that hasn’t improved with other treatments.
  – To qualify, participants must have a pain level of 4 or higher and meet specific health criteria.
• How Does the Study Work?
  – Each person receives a 10cc injection of Wharton’s Jelly into their lower back.
  – There’s no placebo or comparison group—this study is only checking if the treatment is safe and feasible, not comparing it to other treatments.
  – Participants will be followed for one year to track side effects, pain relief, and mobility improvements.
• Is This the Same as Traditional Stem Cell Therapy?
  Not exactly.
  
  – Wharton’s Jelly allograft contains stem cells, but it’s not the same as direct stem cell therapy.
  – Traditional stem cell therapy involves extracting live stem cells from a patient’s bone marrow or fat and reinjecting them.
  – This treatment uses pre-prepared umbilical cord tissue—think of it as a ready-to-use regenerative product rather than a personalized stem cell transplant.
• What Will They Be Measuring?
  – Safety First – Monitoring for side effects and unexpected reactions.
  – Inflammation Levels – Blood tests for C-reactive protein (CRP) and Erythrocyte Sedimentation Rate (ESR) to track inflammation over time.
  – Liver & Kidney Health – Making sure the treatment doesn’t negatively affect organs.
  – Pain & Mobility Improvements
• When Will We See Results?
  – The study just started in March 2024, so don’t expect results soon.
  – Primary completion is set for 2027, with final data expected by 2028.
  – If the results are promising, this could lead to larger trials and eventually a new, non-surgical treatment for back pain sufferers.
  
  For now, it’s a waiting game, but if successful, this could offer a new option for people struggling with chronic back pain!
  

2023 Review on Mesenchymal Stem Cells Treating Back Pain

A 2023 review covering 14 Studies in the British Medical Bulletin explored how mesenchymal stem cells (MSCs) could help treat back pain caused by worn-down spinal discs.

The review concluded that MSCs likely help through signaling, not by becoming new disc cells. While some studies showed MRI improvements like better hydration, the authors found “no conclusive evidence that these reflected MSC differentiation or structural regeneration.” The main benefits appear to come from anti-inflammatory effects and tissue repair signals, not true disc regeneration.

The review also pointed out a few challenges:

• Mixed Results: Not everyone gets the same level of relief.
• Safety Concerns: Rare risks, like infection, need careful monitoring.
• Limited Long-Term Data: More studies are needed to see how long the benefits last.

The takeaway from this particular review? Stem cell therapy is promising for back pain but still experimental and needs more research.

Want to dive deeper into the studies? Check out our detailed article on all the research.

What is the success rate of stem cell therapy for back pain?

Stem cell therapy for back pain shows mixed results. Some studies suggest around 40-53% of patients feel pain relief, and up to 74% see better movement. But these studies weren’t the best, we’ll break it down below.

A closer look at less than 12 studies (you can read more about them on this article) on MSC therapy for lower back pain found:

• Pain Relief
  – About 53.5% of patients reported noticeable pain relief within 6 months.
  – If missing data was assumed to be treatment failure, the worst-case success rate dropped to 40.7%.
• Improved Movement & Function
  – Around 74.3% of patients saw at least 30% better mobility, meaning they could move more easily and handle daily tasks with less discomfort
  – If we assume missing data meant no improvement, that number dropped to 44.1%.

A 2023 review looked at studies on mesenchymal stem cells (MSCs) for lower back pain and found that many patients saw real improvements in pain and mobility. Another review suggests stem cells might help repair worn down spinal discs and reduce inflammation. Potentially a game changer for people who haven’t had success with traditional treatments.

You can read both full reviews here and here.

What Does This Actually Mean?

• Some patients see real relief, but it’s not a guaranteed fix for everyone. (you’ve heard us say that about a few treatments now!)
• There’s no universal success rate because results depend on the patient, the clinic,  the type of stem cells used and cell count.
• Long-term data is still lacking. Most studies only track results for a year or less

Another challenge? Not many large scale trials have been published in the past four years. So a lot of what we know comes from individual clinics rather than independent research.

Best Stem Cell Therapy clinics for Back Pain

We don’t let any clinic just sign up or pay to be listed.

We speak to every clinic directly and review their medical team, the treatments they offer, how their stem cells are sourced and how they follow up with patients after treatment.

We also review licensing documents to confirm they meet the legal and medical standards of the country they operate in. For example, whether cells are processed in a GMP-certified facility or if they provide documentation on stem cell quality.

Clinics must also agree to let us collect and publish independent patient reviews. Both positive and negative.

Why Use Alt Treatment?

We don’t just list clinics, we help you choose the right one, get the best pricing and support you through the entire journey. For free.

Compare with Confidence: Get clinic matches based on your condition, location, and budget.

Ask the Right Questions: Know what to ask before committing

Save on Treatment: Unlock exclusive discounts on vetted clinics and follow-up care.

We’re With You After Treatment: We check in post-treatment and help resolve any issues.

Travel & Visa Help: Need to travel for care? We can help with logistics, documents, and local tips.

Found a Clinic Elsewhere? We’ll check their licensing and track record for you, free of charge.

No Strings Attached: Even if you choose a clinic we don’t partner with, we’re still here to help you make the best decision.

Top Stem Cell Therapy Clinics in Colombia for Back Pain

Umbilical Cord Derived Stem Cells Higher Dosage Treatments Certified Lab

Alevy specializes in stem cell and exosome therapy, using umbilical cord-derived MSCs to treat a wide variety of conditions, from Diabetes, Multiple Sclerosis to Osteoarthritis & Orthopaedic injuries. Their medical team brings over 15 years of experience in pain management, tissue regeneration, and immune system modulation. With three world-class clinics in Medellín, Bogotá, and Pereira, you have options on where you want treatment!

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Umbilical Cord Derived Stem Cells Higher Dosage Treatments Certified Lab

Kyron Stem Cells is a Stem Cell Therapy clinic that focuses on a variety of treatments, including joint pain, chronic fatigue, autoimmune issues, and overall wellness. The clinic is led by Dr. Carlos Rojas, who has been working with stem cells since 1991 and has over a decade of experience in functional and hormone-based medicine. He is known for creating treatment plans that are genuinely personalized, based on each patient’s biology and lab results.

View Full Profile

Top Stem Cell Therapy Clinics in the UK for Back Pain

Orthopaedic Specialist Autologous Stem Cells

Regenesis is a leading UK specialist in Stem Cell Therapy for musculoskeletal & sports injuries. Their team includes some of the UK’s leading orthopedic and pain medicine experts. They’ve got decades of experience in sports medicine and regenerative therapies.

View Full Profile

So, Does Stem Cell Therapy Work for Back Pain?

Honestly, it’s too early to tell. Stem Cell Therapy offers hope for individuals living with spinal cord injuries & back pain. But it might be too early to know if this treatment can deliver consistent, significant improvements. The science is moving forward, and with ongoing research, we may soon see this therapy play a bigger role in recovery. If you are thinking about getting treatment for your back pain be sure to go in with a full understanding that it’s early days!

If you want to read about other areas Stem Cells can help with, check out our article on What conditions can Stem Cell Therapy help with!

What does Alt Treatment do?

Alt Treatment is a free, independent platform that helps you understand stem cell therapy & decide if it’s right for you.

We break down complex information into clear, honest guidance. When you’re ready, we can connect you with verified clinics that meet your needs, in the right location, and often with exclusive discounts.

There’s no charge to use our platform. No hidden fees. No pressure. Our main aim is to genuinely help you figure out if treatment is right & the best places to consider.

If you want to talk, fill out our form here & our personal concierge team will reach out.

What Conditions Can Be Treated With Stem Cell Therapy?

Stem cell therapy primarily treats orthopedic issues like osteoarthritis and tendon injuries by repairing tissues and reducing pain. It’s also popular for treating blood disorders and is making waves in cosmetic treatments for skin rejuvenation.
There are also exciting possibilities in other areas. Like neurodegenerative and autoimmune diseases, but these uses are less common. And research is still catching up. Stem cell therapy is always evolving, so keep an eye on this space!
If you want to know more, check out our Areas of Treatment Section

Does insurance cover Stem Cell Therapy for back pain?

No, insurance companies won’t cover stem cell therapy for back pain because they still classify it as experimental.

What is the Success Rate of Stem Cell Therapy?

Honestly, the success rates can vary from person to person and the treatment you’re getting! To learn more about how stem cell therapy works, check out our article on What is Stem Cell Therapy.

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