Japan is a major player in regenerative medicine, with Stem Cell Therapy at the forefront. However, it’s not always clear cut.
In this article, we’ll cover everything you need to know about Stem Cell Therapy in Japan, including its legality, costs & key cities offering these treatments.
Our team is here to help you understand what treatments you can get in South Korea safely, compare how Korean Stem Cell costs stack up against other countries & which clinics you can trust.
Alt Treatment Vetting Guarantee
All prices are updated as of December 2025. Our pricing data is attained from real clinics in Japan and verified patient treatment data. Legal Data is obtained directly from official government sources (Japan’s MHLW) and is reviewed monthly.
Are Stem Cells Legal in Japan in 2025?
Yes, Stem Cell Therapy is legal in Japan, with regulations under the Act on the Safety of Regenerative Medicine (ASRM). Japan has one of the most structured frameworks for regenerative medicine.
Now this doesn’t mean all treatments are officially approved. This act means if clinics submit treatment plans to the government & they are accepted, they can perform these treatments. But they’re still classed as experimental.
To see which treatments have received official marketing approval, Japan’s PDMA lists them all on this section of their website.
How Japan Regulates Stem Cell Therapy
Japan has a three-tiered regulatory system under the Act on the Safety of Regenerative Medicine (ASRM) and Pharmaceutical and Medical Device Act (PMDA), categorizing treatments based on their risk level and level of manipulation. For simplicity, we’ll cover the first 2:
- Category 1 (Highest Risk):
- Banned for Commercial Use: Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are strictly banned for clinical treatments at private clinics. (page 3 of the MLHW Guidelines).
- Banned for Commercial Use: Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are strictly banned for clinical treatments at private clinics. (page 3 of the MLHW Guidelines).
- Category 2 (Moderate Risk):
- Allowed for Treatment: Expanded/cultured autologous stem cells (stem cells from you that have been multiplied in a lab) are allowed for treatment at private clinics with government approval
- Not Offered by Clinics: Umbilical cord-derived mesenchymal stem cells (UC-MSCs) are not available for patient treatments at private clinics. Due to stricter approval requirements, UC-MSCs are currently only used in clinical trials or research settings. Here is the MHLW Guidelines on Clinical Research Using Human Stem Cells- source
View pre-vetted, government approved clinics in Japan
Browse verified stem cell clinics in Japan & around Asia that we’ve already personally vetted.
Browse Verified Stem Cell ClinicsHow do Stem Cell Therapy clinics in Japan get approval?
So, there are clinics in Japan operating without approval. If you’re speaking to any, make sure you ask them if they have the relevant treatment approval. For example, if you’re getting Parkinson’s treatment, they’ll have a specific neurological certificate for this. Here’s the actual process Stem Cell clinics in Japan go through to get approval for each treatment:
Submit Treatment Plan
Submit their treatment plan for a review by a certified Special regenerative medicine committee.
Minister of Health Review
The plan is evaluated for:
- Whether an in-house or outsourced lab is used and if it meets government standards.
- The clinic’s medical team qualifications in regenerative medicine.
Additionally, new on site inspection powers from 2025 allows officials to do more random or targeted inspections to ensure clinics are following standards.
Stem Cell options in Japan
- Allowed Treatments: Many clinics use autologous stem cells (from your own body) for conditions like arthritis, chronic pain, and neurological issues.
- Cultured Cells: Japan allows treatments with lab-grown cells, which means higher cell counts and potentially more effective therapies.
- Prohibited Practices: Therapies using embryonic stem cells or unproven experimental treatments are restricted unless they’re part of approved clinical trials.
- Mesenchymal Stem Cells (MSCs) from Umbilical Cord Tissue: Not provided by clinics for treatments.
- Embryonic stem cells (ESCs) & IPSC cells are NOT allowed for treatment
- Ethical Considerations: Clinics must follow ethical practices, including informed consent and clear documentation.
With its clear guidelines and focus on innovation, Japan’s become a leader in regenerative medicine, it’s a great option!.
To read more about the Stem Cell Therapy treatment process as a whole, check out our guide on How Stem Cell Treatments work.
Want to know if Stem Cells can actually help your condition?
Is Parkinson’s Stem Cell Treatment approved in Japan in 2025?
No, Stem Cell treatment for Parkinson’s isn’t officially approved in Japan as of August 2025. But some clinics can still offer it as a regulated experimental treatment if their treatment plans have been accepted by the Ministry of Health, Labour & Welfare.
Japan’s national drug regulator, the Pharmaceuticals and Medical Devices Agency (PMDA) has not granted marketing approval for any stem cell product to treat Parkinson’s disease. All officially approved stem cell treatments are on the PDMA’s website.
A PMDA approval means a product has been proven safe and effective for a specific condition and can be marketed nationwide.
ASRM permission, on the other hand, only applies to the clinic that filed the plan and is more like a hospital being allowed to run a closely monitored procedure. These ASRM treatments are still considered experimental, even though they’re regulated and legal in Japan.
Normally, clinics will display their certificates on their website. There will be specific certificates for specific conditions. At Alt Treatment, we do all these checks before selecting which Japanese clinics can appear on our platform.
Has Autism Stem Cell Treatment been approved in Japan yet?
No, as of August 2025, stem cell therapy for autism isn’t officially approved in Japan. But there are a few clinics that have had Autism specific treatment plans accepted and can offer treatment.
Are Stem Cells expensive in Japan?
Stem cell therapy in Japan is more expensive than countries like Thailand, US & Australia.
We’ve gathered our pricing data in a few different ways & we’re always updating it!
But, Japan is one of the most regulated countries when it comes to Stem Cell Therapy & offers a much wider variety of treatments then countries like the US, Canada, Australia & Singapore.
Stem Cell Therapy Cost Japan as of August 2025
Stem Cell Therapy prices in Japan vary from $3,500 to $35,000, with neurological conditions being the most expensive. Here’s a more detailed breakdown that we’ve gathered from patients, Clinics & online sources directly:
| Condition | Cost (¥ Yen) | Cost $ (USD) | Cost $ (AUD) |
| Neurological | ¥2,000,000–¥5,000,000 | $14,000–$35,000 | $21,000 – $53,000 |
| Diabetes | ¥2,200,000 | $15,000 | $22,700 |
| Orthopedic | ¥1,320,000 – ¥2,200,000 | $6,900 – $15,000 | $13,600 – $22,700 |
| Skin & Hair | ¥500,000 – ¥2,200,000 | $3,500 – $15,000 | $5,300 -$22,700 |
| Erectile Dysfunction | ¥1,600,700 – ¥2,200,000 | $11,000 – $15,000 | $16,600 – $22,700 |
| Multiple Sclerosis | ¥2,000,000 – ¥3,500,000 | $14,000 – $22,500 | $21,000 – $34,000 |
Want to compare prices across different countries? Read our full breakdown of average stem cell therapy costs worldwide
Not sure if you should get stem cell treatment? We’ll help you decide. We’ll walk you through real data on success rates for each condition, stem cell treatments that don’t work & how to avoid poor clinics.
Knee Stem Cell Treatment Price in Japan
In Japan, Stem Cell Treatment prices for Knee issues like Osteoarthritis range from $6,900 for one knee & up to $9,500 (USD) for both knees. Factors that affect price are:
- With Knee OA being more common, clinics do offer lower prices here then for other orthopedic conditions, hence the difference with this price & the price in the table above.
- As you’re getting multiple treatments, there’s normally a discount in place for two knees.
- Cell Dosage. Depending on the dosage you’re prescribed and the severity of your Knee issue
- Most treatments will be delivered via a localized injection, so this won’t affect price typically.
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Is Japan worth it for Stem Cell Treatment?
Yes! Japan is definitely a good option for Stem Cell Treatment:
It’s not perfect of course, but if you can manage staying for 6 weeks or making two trips, it’s somewhere you should definitely consider. Here’s more detail:
- Leading the Way in Research: Japan is home to Shinya Yamanaka, the Nobel Prize-winning scientist who pioneered iPSC research. His work continues to shape treatments worldwide.
- Access to Advanced Treatments: The country’s unique regulatory system (ASRM) allows patients to try new therapies before full clinical trials are complete, something not many countries offer.
- Cutting-Edge Clinics: Many clinics in Japan use cultured stem cells and advanced techniques to provide patients with high-quality care.
- Focus on Patient Care: Japan’s culture of precision and well-being ensures treatments are delivered with careful attention to detail, putting patients first
Whilst Japan is an amazing desintation for Stem Cell Therapy – if you did want to read more about what treatments are like in other countries, check out our article on the Best Countries for Stem Cell Therapy!
Top Stem Cell Therapy clinics in Japan
We don’t let any clinic just sign up or pay to be listed.
We speak to every clinic directly and review their medical team, the treatments they offer, how their stem cells are sourced and how they follow up with patients after treatment.
We also review licensing documents to confirm they meet the legal and medical standards of the country they operate in. For example, whether cells are processed in a GMP-certified facility or if they provide documentation on stem cell quality.
Clinics must also agree to let us collect and publish independent patient reviews. Both positive and negative.
Why Use Alt Treatment?
We don’t just list clinics, we help you choose the right one, get the best pricing and support you through the entire journey. For free.
Compare with Confidence: Get clinic matches based on your condition, location, and budget.
Ask the Right Questions: Know what to ask before committing
Save on Treatment: Unlock exclusive discounts on vetted clinics and follow-up care.
We’re With You After Treatment: We check in post-treatment and help resolve any issues.
Travel & Visa Help: Need to travel for care? We can help with logistics, documents, and local tips.
Found a Clinic Elsewhere? We’ll check their licensing and track record for you, free of charge.
No Strings Attached: Even if you choose a clinic we don’t partner with, we’re still here to help you make the best decision.
Top Stem Cell Therapy Clinics in Japan
Based in Tokyo, Japan, Helene Clinic was one of the first Stem Cell Therapy clinics in Japan to be approved under the Regenerative Medicine Provision Plan. They’re one of the few clinics that have authorization to offer over 5 different stem cell treatments.
View Full Profile
Based in Osaka, Clinique Haru is led by Dr Haruhiko Nishida, who has over 30 years experience as an orthopedic surgeon. Specialists in orthopedic treatments, they have official authorization to perform Stem Cell treatments for Osteoarthritis and chronic pain conditions. Working with a GMP accredited facility to culture their stem cells, their clinic offers high levels of quality along with true orthopedic specialists.
View Full ProfileDo I Need a Visa for Stem Cell Treatment in Japan?
If you’re traveling to Japan for stem cell therapy, your visa requirements depend on your nationality and length of stay.
- USA, UK, Canada, Australia, Singapore: You can enter visa-free for up to 90 days, which covers medical consultations and short-term treatments.
- For Stem Cell Therapy (Which Requires Two Visits): Since most treatments involve multiple trips, a multiple-entry Visa for Medical Stay is recommended so you don’t have to apply twice.
- How to Apply: You’ll need a medical treatment plan from your clinic in Japan, and a local medical institution or guarantor will assist with your application.
For the latest visa details, check with the Japanese embassy in your country or check out the medical visa page on the government website here.
Top Cities for Stem Cell Therapy in Japan
Stem Cell Therapy in Tokyo
As the capital, Tokyo is home to some of Japan’s most advanced hospitals and private clinics specializing in regenerative medicine. Patients here have access to a broad range of treatments, including cutting-edge therapies for conditions like arthritis and neurological disorders. The city’s reputation for innovation makes it a popular choice for both locals and international visitors.
To read more about Tokyo as a destination for Stem Cell Treatments, take a loot at our Tokyo Stem Cell Treatment guide.
Stem Cell Therapy in Osaka
Osaka combines its reputation for innovation with a patient-focused approach to care. Clinics in this city often feature advanced technologies, like cultured stem cells, and emphasize personalized treatment plans. For those seeking expert care with a human touch, Osaka is an excellent option.
To learn about Osaka as a potential city to visit for Stem Cell Therapy, our Osaka Stem Cell Therapy article will be useful.
Stem Cell Therapy in Kyoto
Kyoto stands out as the birthplace of Shinya Yamanaka’s Nobel Prize-winning iPSC research. Beyond its rich history in science, Kyoto offers a selection of specialized clinics focused on applying this groundbreaking technology to real-world treatments. Patients visiting Kyoto can expect to benefit from the latest in stem cell innovation.
Is Stem Cell Therapy in Japan better than Stem Cell Treatments in Australia & Singapore?
For most people yes, Stem Cell Therapy is better in Japan then Australia & Singapore. We look at the differences in treatment between Japan, Australia & Singapore for Stem Cell Therapy:
| Country | Cultured Cells Allowed | Stem Cell Treatment Options | Average Cost of Stem Cell Treatment |
| Japan | Yes | Varied | $3,500 – $35,000 |
| Australia | No | Orthopaedic | $4,500 – $13,000 |
| Singapore | No | Minimal | N/A |
Stem Cell Treatments in Japan vs. Colombia & the US
| Factor | Japan | Colombia | US |
|---|---|---|---|
| Regulations | Strict | Flexible | Strict |
| Cultured Cells | Allowed | Allowed | Not Allowed |
| Types of Cells used | Patients own Fat-derived MSC Cells | Umbilical Cord Derived MSC Cells | Patient’s own Bone Marrow derived MSC Cells. Umbilical Cord Derived Cells allowed in 2 states |
If you want to compare stem cell treatments in Japan to other countries, we’ve put together an article looking at the Best Countries for Stem Cell Therapy to help you out!
Risks of getting Stem Cell Treatment in Japan
While Japan has strict regulations, it’s essential to be aware of potential risks:
🏥 Clinic Quality Variability
Whilst Japan does have government approved clinics, remember not all clinics operate to these standards. Here at Alt Treatment, we’re only working with government approved clinics who have certifications for each treatment they’re offering.
🗣️ English Speaking Support
Not all clinics offer English speaking support and documentation.
💰 Price Hikes
A lot of clinics do increase prices when dealing with foreigners. We’ve secured exclusive pricing & discounts to ensure you’re paying the best price possible.
⚠️ Risks & Side Effects
Remember, as with any country, side effects from poor quality clinics are always possible.
Read these before booking any consultations
Latest Advances in Stem Cell Treatments in Japan
Japan is leading the charge in stem cell innovation, making significant strides in both research and treatment:
- Advances in iPSC Research: With Nobel Prize-winning scientist Shinya Yamanaka at the helm, Japan has become a global leader in iPSC technology, exploring its potential for treating degenerative diseases and even organ repair.
- Strong Government Support: Backed by generous funding and international collaborations, Japan is pushing the boundaries of what stem cell therapy can achieve.
- Progress in Clinical Trials: Japan is actively testing therapies for conditions like Parkinson’s disease, spinal cord injuries and heart failure.
- World’s First iPSC Spinal Cord Injury Trial:
Researchers at Keio University conducted one of the world’s first clinical studies using iPSC-derived nerve cells for spinal cord injury. These special cells were injected into the patient’s spine just a few weeks after the injury. It’s a huge moment for regenerative medicine.
Early results suggest potential for future therapies, but this research is still in early stages and not a proven treatment. It’s covered in more detail here. - On August 5th 2025, Sumitomo Pharma announced in a press release they have submitted an application to approve their IPSC Stem cell treatment for Parkinson’s disease. It’s called Raguneprocel. In simple terms, they are donor-derived iPSC cells reprogrammed into early nerve cells (dopaminergic neural progenitor cells) to improve motor function in people with advanced Parkinson’s disease.
Travel Concierge Service in Japan
Undergoing treatment often requires staying in Japan for up to 6 weeks.
For many patients, navigating a foreign country for this long can be overwhelming. Trying to figure out the best areas to stay, or managing daily tasks like grocery shopping and arranging tours.
Should I get Stem Cell Therapy in Japan?
If you’re aware of all the risks around Stem Cell Therapy for your specific condition, then yes, Japan is a country you should consider for Stem Cell Treatment. But, remember these points:
- They will only use Mesenchymal Stem Cells from your own fat tissue
- The culturing or process around “growing your cells in a lab” takes 4-5 weeks. Meaning you either have to visit Japan twice or stay there for the entire duration
- Not all clinics are government approved. You still need to be ultra careful when selecting which clinics to visit
- Most clinics won’t offer post treatment support. If you’re visiting from outside the country, this is something to consider.
This is where we come in. Our team is here to help you understand what treatments you can get in Japan safely, explain how to get the best pricing & which clinics you can trust. We also support you through the entire journey, including post treatment support.
Get Free Support From Alt Treatment
- Walk you through latest data & independent patient reviews
- Guidance on regulations across countries globally
- Connects you with vetted clinics who follow best practice
- Secure exclusive discounts on treatments
- Support throughout your journey. Think of us as your free, personal concierge!
Alt Treatment is a free, independent platform that helps you understand stem cell therapy & decide if it’s right for you.
We break down complex information into clear, honest guidance. When you’re ready, we can connect you with verified clinics that meet your needs, in the right location, and often with exclusive discounts.
There’s no charge to use our platform. No hidden fees. No pressure. Our main aim is to genuinely help you figure out if treatment is right & the best places to consider.
If you want to talk, fill out our form here & our personal concierge team will reach out.
Yes, it is legal and regulated under the Act on the Safety of Regenerative Medicine.
Most insurance plans do not cover Stem Cell Therapy in Japan.
Common side effects of getting Stem Cells are fever and local pain/swelling at the injection site. We go into all of the side effects in more detail in our Stem Cell Therapy Side Effects Article
Stem Cell Therapyは 「幹細胞治療（かんさいぼうちりょう）」 と訳されます。これは、幹細胞を使用して損傷した組織を修復し、病気を治療する再生医療の一種です。
日本の幹細胞治療の費用は ¥500,000〜¥5,000,000（約$3,500〜$35,000 USD） で、治療の種類によって異なります。インドやタイより高いですが、アメリカやオーストラリアより安く、技術と規制のバランスが取れています。例えば、整形外科的治療は ¥650,000〜¥3,000,000、神経疾患の治療は ¥2,000,000〜¥5,000,000、アンチエイジング治療は ¥500,000〜¥1,500,000 です。一部のクリニックでは分割払いのオプションも提供しています。
일본의 줄기세포 치료 비용은 **₩4,500,000~₩45,000,000 (약 $3,500~$35,000 USD)**이며, 치료 유형에 따라 달라집니다. 인도나 태국보다 비싸지만 미국이나 호주보다는 저렴하며, 높은 기술력과 엄격한 규제를 갖추고 있습니다.
예를 들어:
정형외과 치료: ₩5,800,000~₩27,000,000
신경 질환 치료: ₩18,000,000~₩45,000,000
항노화 치료: ₩4,500,000~₩13,500,000
일부 클리닉에서는 분할 결제 옵션도 제공하고 있습니다.
Yes, Stem Cel Treatment can help your knee pain by reducing inflammation and supporting the body’s natural healing process. There’s a few different types of Stem cell treatments for knee issues, our article on Stem Cells for Knee conditions goes into more detail.
Both countries are good options. We put together a full comparison of legal regulation, treatment options & costs.
Read our Japan & South Korea Comparison guide to learn more.
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